{"schemaVersion":"1.0","generatedFrom":"https://brightaifuture.com/discoveries/proteome","record":{"id":"proteome","headline":"A broader map of human proteins.","canonicalUrl":"https://brightaifuture.com/discoveries/proteome","datePublished":"2026-09-05","dateModified":null,"sourcePublicationDate":"2021-07-22","author":null,"publisher":{"name":"Bright AI Future","url":"https://brightaifuture.com/"},"topics":["biology"],"summary":"Researchers applied AlphaFold to a broad collection of human proteins.","evidenceState":"Demonstrated","keyFacts":[{"label":"AI’s role","value":"AlphaFold predicted structures across the human proteome."},{"label":"Documented result","value":"The study supplied predictions with per-region confidence estimates."},{"label":"Important limitation","value":"Coverage is not uniform accuracy; disordered regions and low-confidence predictions need care."}],"limitations":["Coverage is not uniform accuracy; disordered regions and low-confidence predictions need care."],"evidenceLinks":[{"title":"Highly accurate protein structure prediction for the human proteome","url":"https://www.nature.com/articles/s41586-021-03828-1","type":"paper"}],"evidencePackUrl":"https://brightaifuture.com/evidence-pack/proteome","embedUrl":"https://brightaifuture.com/embed/story/proteome","attribution":{"credit":"Bright AI Future","requirements":["Link to the canonical Bright record.","Keep material limitations with the claim they qualify.","Link to the original evidence when repeating a substantive claim.","Do not describe a source check or organization-reported result as independent verification."],"sourceRights":"Linked source material, quotations, trademarks and media remain subject to their owners’ terms. No reuse right is granted for third-party media."}},"claim":{"humanProblem":"Many human proteins lacked experimentally determined structures.","priorConstraint":"Structural coverage was incomplete and uneven.","aiRole":"AlphaFold predicted structures across the human proteome.","documentedResult":"The study supplied predictions with per-region confidence estimates.","whyItMayMatter":"Scientists could investigate previously less accessible protein regions.","unresolvedQuestions":["Combine predictions with experimental biology."]},"evidenceAssessment":{"state":"Demonstrated","claimConfidence":"unassessed","reviewState":"source-checked","reviewMethod":null,"reviewNote":"Legacy source check; no named human reviewer is recorded in this projection.","lastSourceReview":"2026-09-05","independentVerification":"not-established-by-this-source-review"},"sources":[{"id":"source:proteome","title":"Highly accurate protein structure prediction for the human proteome","url":"https://www.nature.com/articles/s41586-021-03828-1","type":"paper"}],"revisions":[],"corrections":[]}