Bright key facts / Demonstrated
Seeing the shape of life.
Researchers used AlphaFold to predict protein structures with accuracy competitive with experimental structures on many CASP14 targets. Bright's interactive p53 view uses a separate, later AlphaFold DB prediction: human p53 AF-P04637-F1 model v6, created on 2025-08-01.
- AI’s role
- A neural network integrated sequence and structural information to predict three-dimensional structure.
- Documented result
- The 2021 AlphaFold2 paper reported strong performance in the blind CASP14 assessment. On September 24, 2026, AlphaFold Database separately added high-confidence predictions covering 2,812 viral proteomes: 5,279 heterodimers and 2,749 homodimers, plus 4,681 high-confidence homodimers from the separate Viral Assembly Database collection.
- Important limitation
- Predictions carry uncertainty. A predicted structure does not establish function, interaction in a living system, vaccine efficacy or treatment benefit.