Bright key facts / Demonstrated
Personalizing an ablation for persistent AF
A multicenter randomized, controlled, double-blind superiority trial tested whether adding AI-detected spatio-temporal electrogram-dispersion targets to pulmonary-vein isolation improves treatment of drug-refractory persistent atrial fibrillation.
- AI’s role
- An AI algorithm detected areas of spatio-temporal electrogram dispersion for the tailored ablation arm, in addition to pulmonary-vein isolation.
- Documented result
- At 12 months after a single ablation, 88% of the tailored arm (n=187) versus 70% of the PVI-only arm (n=183) met the primary efficacy endpoint: freedom from documented atrial fibrillation with or without antiarrhythmic drugs (P<0.0001 for superiority).
- Important limitation
- There was no significant between-arm difference in freedom from any atrial arrhythmia after one ablation.